Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia.

@article{Skelly2012TempolAP,
  title={Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia.},
  author={J Richard Skelly and Deirdre Edge and Christine M Shortt and James F. X. Jones and Aidan Bradford and Ken D O'Halloran},
  journal={American journal of respiratory cell and molecular biology},
  year={2012},
  volume={46 2},
  pages={139-48}
}
Respiratory muscle dysfunction is implicated in the pathophysiology of obstructive sleep apnea syndrome (OSAS), an oxidative stress disorder prevalent in men. Pharmacotherapy for OSAS is an attractive option, and antioxidant treatments may prove beneficial. We examined the effects of chronic intermittent hypoxia (CIH) on breathing and pharyngeal dilator muscle structure and function in male and female rats. Additionally, we tested the efficacy of antioxidant treatment in preventing (chronic… CONTINUE READING