Tempo and Mode in the Endocannaboinoid System

@article{McPartland2007TempoAM,
  title={Tempo and Mode in the Endocannaboinoid System},
  author={John M. McPartland and Ryan W. Norris and C. William Kilpatrick},
  journal={Journal of Molecular Evolution},
  year={2007},
  volume={65},
  pages={267-276}
}
The best-known endocannabinoid ligands, anandamide and 2-AG, signal at least seven receptors and involve ten metabolic enzymes. Genes for the receptors and enzymes were examined for heterogeneities in tempo (relative rate of evolution, RRE) and mode (selection pressure, Ka/Ks) in six organisms with sequenced genomes. BLAST identified orthologs as reciprocal… CONTINUE READING