Templated open flocs of anisotropic particles for pulmonary delivery with pressurized metered dose inhalers.

@article{Tam2010TemplatedOF,
  title={Templated open flocs of anisotropic particles for pulmonary delivery with pressurized metered dose inhalers.},
  author={Jasmine Man-Chi Tam and Josh D. Engstrom and Domingo Ferrer and Robert O Williams and Keith P. Johnston},
  journal={Journal of pharmaceutical sciences},
  year={2010},
  volume={99 7},
  pages={
          3150-65
        }
}
The challenges in forming stable drug suspensions in hydrofluoroalkane (HFA) propellants have limited drug dosages and efficiency of drug delivery with pressurized metered dose inhalers (pMDI). Herein, stable suspensions of weakly flocculated particles, in the shape of thin plates or needles, of a poorly water-soluble drug, itraconazole (Itz), are efficiently delivered by pMDI at high doses, up to 2.4 mg/actuation. These anisotropic particles pack inefficiently and form low-density flocs that… CONTINUE READING
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