Template switching during break-induced replication

@article{Smith2007TemplateSD,
  title={Template switching during break-induced replication},
  author={Catherine E. Smith and Bertrand Llorente and Lorraine S. Symington},
  journal={Nature},
  year={2007},
  volume={447},
  pages={102-105}
}
DNA double-strand breaks (DSBs) are potentially lethal lesions that arise spontaneously during normal cellular metabolism, as a consequence of environmental genotoxins or radiation, or during programmed recombination processes. Repair of DSBs by homologous recombination generally occurs by gene conversion resulting from transfer of information from an intact donor duplex to both ends of the break site of the broken chromosome. In mitotic cells, gene conversion is rarely associated with… 
Break-induced replication: What is it and what is it for?
Homologous recombination (HR) is considered to be an error-free mechanism for the repair of DNA double-strand breaks (DSBs). Indeed, most DSB repair events occur by a non-crossover mechanism limiting
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TLDR
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TLDR
This study provides evidence for a role of SSEs at multiple steps during BIR, thus participating in the destabilization of the genome by generating complex chromosomal rearrangements.
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TLDR
The BIR defect observed for rad51 mutants is due to strand invasion failure, whereas the Pol δ complex mutants are proficient for strand invasion but unable to complete extensive tracts of recombination-initiated DNA synthesis.
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TLDR
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Template Switching During Break-Induced Replication Is Promoted by the Mph1 Helicase in Saccharomyces cerevisiae
TLDR
A modification of the transformation-based assay is described to facilitate detection of switching between donor templates during BIR by genetic selection in diploid yeast and shows that the Mus81, Rad1, and Yen1 structure-selective nucleases act redundantly to facilitate BIR.
Single-strand annealing between inverted DNA repeats: Pathway choice, participating proteins, and genome destabilizing consequences
TLDR
It is reported that inverted DNA repeats (IRs) placed near a DSB can channel its repair from an accurate pathway that leads to gene conversion to instead a break-induced replication (BIR) pathway that leading to genetic instabilities.
Break-Induced Replication and Genome Stability
Genetic instabilities, including mutations and chromosomal rearrangements, lead to cancer and other diseases in humans and play an important role in evolution. A frequent cause of genetic
Break-induced replication mechanisms in yeast and mammals.
TLDR
A series of systematic studies utilizing site-specific DNA breaks for BIR initiation in mammalian reporters led to the discovery of highly efficient RAD51-dependent BIR, allowing side-by side comparison with BIR in yeast which is the focus of this review.
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