Template-directed oligonucleotide ligation on hydroxylapatite

@article{Acevedo1986TemplatedirectedOL,
  title={Template-directed oligonucleotide ligation on hydroxylapatite},
  author={O. Acevedo and L. Orgel},
  journal={Nature},
  year={1986},
  volume={321},
  pages={790-792}
}
Bernal1, and subsequently other authors2, have suggested that the prebiotic synthesis of the precursors of biopolymers could have occurred on a solid surface such as that provided by clay or some other mineral. The separation of products from the other components of the reaction mixture in such a system is reminiscent of modern solid-phase synthesis of polypeptides and polynucleotides. One such scheme envisages that growing polymers were localized by adsorption to a mineral surface where an… Expand
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