Template-directed nonenzymatic oligonucleotide synthesis: lessons from synthetic chemistry

@article{Fahrenbach2015TemplatedirectedNO,
  title={Template-directed nonenzymatic oligonucleotide synthesis: lessons from synthetic chemistry},
  author={A. Fahrenbach},
  journal={Pure and Applied Chemistry},
  year={2015},
  volume={87},
  pages={205 - 218}
}
Abstract The nonenzymatic synthesis of nucleic acids, in particular, RNA, and the template-directed synthesis of artificial organic molecules, such as macrocycles, catenanes and rotaxanes, have both undergone significant development since the last half of the 20th century. The intersection of these two fields affords insights into how template effects can lead to information copying and storage at the molecular level. Mechanistic examples of model template-directed RNA replication experiments… Expand

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