Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis.

@article{Lack2009TemperatureSO,
  title={Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis.},
  author={Nathan A. Lack and Akane Kawamura and Elizabeth Fullam and Nicola Laurieri and Stacey Beard and Angela J. Russell and Dimitrios Evangelopoulos and Isaac M. Westwood and Edith Sim},
  journal={The Biochemical journal},
  year={2009},
  volume={418 2},
  pages={369-78}
}
In Mycobacterium tuberculosis, the genes hsaD (2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase) and nat (arylamine N-acetyltransferase) are essential for survival inside of host macrophages. These genes act as an operon and have been suggested to be involved in cholesterol metabolism. However, the role of NAT in this catabolic pathway has not been determined. In an effort to better understand the function of these proteins, we have expressed, purified and characterized TBNAT (NAT from M… CONTINUE READING
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