Temperature-sensitive mutants of foot-and-mouth disease virus: the isolation of mutants and observations on their properties and genetic recombination.

@article{Mackenzie1975TemperaturesensitiveMO,
  title={Temperature-sensitive mutants of foot-and-mouth disease virus: the isolation of mutants and observations on their properties and genetic recombination.},
  author={John S. Mackenzie and W R Slade and Julie-anne Lake and Robert A. J. Priston and J A Bisby and Susan Laing and Julie Newman},
  journal={The Journal of general virology},
  year={1975},
  volume={27 1},
  pages={61-70}
}
A number of temperature-sensitive mutants were isolated from two strains of foot-and-mouth disease virus (FMDV). Various properties of the mutants were examined including comparative growth curves at permissive and restrictive temperatures, cut-off temperatures, thermal lability and pH sensitivity. Recombination was observed between various pairs of mutants of FMDV strain Pacheco. It occurred early in the growth cycle and the proportion of recombinants remained constant thereafter. Maximum… CONTINUE READING

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( I 973 ) - A prel iminary s tudy of physiological characterist ics o f temperature - sensitive mutants of influenza virus

C. R. LE, W. R. SLADE, P. ELWORTHY, M. O'SULLIVAN
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Improved technique for the isolat ion of temperature - sensi t ive mu tan t s of foot - and - mouth disease virus

J. S. MACKENZIE, N. J. DIMMOCK
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