Temperature-sensitive gating of cation current in guinea pig ileal muscle activated by hyperpolarization.

  title={Temperature-sensitive gating of cation current in guinea pig ileal muscle activated by hyperpolarization.},
  author={Hirotaka Yanagida and Ryuji Inoue and Miharu Tanaka and Yasuo Ito},
  journal={American journal of physiology. Cell physiology},
  volume={278 1},
The temperature dependence of hyperpolarization-activated current (I(h)) was investigated in freshly isolated guinea pig ileal smooth muscle cells, using the nystatin-perforated whole cell recording technique. Hyperpolarizing pulses (-50 to -120 mV) from -40 mV evoked time-dependent inward rectifying currents with a reversal potential of -33 mV and a slow activation time course well approximated by a single exponential. The properties of these currents, such as steady-state variables… CONTINUE READING
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Physiological significance of hyperpolarization-activated current (If) in the pace-making activity of guinea-pig small intestine

  • H. Yanagida, R. Inoue, Y. Ito
  • Jpn. J. Pharmacol. 76, Suppl. I: 110P,
  • 1998
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