Temperature-sensitive adult liver cell line dependent on glucocorticoid for differentiation.

  title={Temperature-sensitive adult liver cell line dependent on glucocorticoid for differentiation.},
  author={Janice Y Chou},
  journal={Molecular and cellular biology},
  volume={3 6},
A clonal rat adult hepatocyte cell line (RALA255-10G) was shown to be temperature sensitive (ts) for growth and differentiation. Glucocorticoid was necessary to maintain the maximal levels of differentiated functions in these cells. The RALA255-10G cell line was established by transforming primary adult hepatocytes with simian virus 40 tsA255 virus that is temperature sensitive for maintenance of transformation. At the permissive temperature (33 degrees C), RALA255-10G cells showed… CONTINUE READING

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