Temperature-sensitive RNA polymerase mutants of a picornavfrus ( foot-and-mouth disease virus / conditional-lethal isoelectric focusing / reversion / thermal inactivation of transcription )

@inproceedings{LoweTemperaturesensitiveRP,
  title={Temperature-sensitive RNA polymerase mutants of a picornavfrus ( foot-and-mouth disease virus / conditional-lethal isoelectric focusing / reversion / thermal inactivation of transcription )},
  author={Peter A. Lowe and ANDREW M. Q. KINGt and DAVID MCCAHONt and Fred L. Brown and JOHN W. I. NEWMANt}
}
Temperature-sensitive (ts) RNA polymerase mutants of a picornavirus are reported, Two foot-and-mouth disease virus (FMDV) mutants designated ts 22 and to 115 have been characterized. As judged by isoelectric focusing, both have charge alterations in P56a, the FMDV RNA polymerase protein. Virus RNA synthesis in cells infected with the mutants is severely… CONTINUE READING