Temperature selectivity in reversed-phase high performance liquid chromatography.

  title={Temperature selectivity in reversed-phase high performance liquid chromatography.},
  author={John W. Dolan},
  journal={Journal of chromatography. A},
  volume={965 1-2},
Column temperature plays two important roles in reversed-phase high-performance liquid chromatography (RP-HPLC): control of retention (k) and control of selectivity (a). While changes in retention as a function of temperature are ubiquitous, selectivity changes for any given solute pair are more pronounced for ionized samples and samples with more polar substituents. With many samples, column temperature can be selected in a manner that optimizes resolution. The selectivity effects observed for… CONTINUE READING

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