Temperature responses in rats after acute and chronic administrations of caffeine.

@article{Schlosberg1983TemperatureRI,
  title={Temperature responses in rats after acute and chronic administrations of caffeine.},
  author={Arthur J. Schlosberg},
  journal={Pharmacology, biochemistry, and behavior},
  year={1983},
  volume={18 6},
  pages={935-42}
}
Acute administrations (IP) of caffeine produced dose-dependent changes in the body temperature of rats. Low doses (12.5 and 25 mg/kg) induced hyperthermia soon after drug administration, while high doses (50 and 100 mg/kg) produced maximal hypothermia approximately 2 hr later. The acute effects of caffeine were also dependent on ambient temperature. The hyperthermic and hypothermic responses were attenuated and blocked, respectively, in rats maintained at 32 degrees C. At 4 degrees C, the… CONTINUE READING