Temperature resolved second harmonic generation to probe the structural purity of m-hydroxybenzoic acid

@article{Clevers2012TemperatureRS,
  title={Temperature resolved second harmonic generation to probe the structural purity of m-hydroxybenzoic acid},
  author={S. Clevers and F. Simon and V. Dupray and G. Coquerel},
  journal={Journal of Thermal Analysis and Calorimetry},
  year={2012},
  volume={112},
  pages={271-277}
}
We report the use of second harmonic generation (SHG) and temperature resolved second harmonic generation (TR-SHG) for in situ probing and monitoring the structural purification of m-hydroxybenzoic acid (MHBA). Pure and mixtures of the two polymorphic forms of MHBA (metastable Pna21 and stable P21/c) and commercial MHBA were analysed by: DSC, XRPD and SHG. Results obtained with these three techniques are compared and demonstrate for that particular component, the high sensitivity and accuracy… Expand
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