Temperature modulation reveals three distinct stages of Wallerian degeneration.

  title={Temperature modulation reveals three distinct stages of Wallerian degeneration.},
  author={J W Tsao and Edwin B. George and John Wesley Griffin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={19 12},
After peripheral nerve transection, axons distal to the cut site rapidly degenerate, a process termed Wallerian degeneration. In wild-type mice the compound action potential (CAP) disappears by 3 d. Previous studies have demonstrated that cold temperatures and lower extracellular calcium ion (Ca2+) concentrations can slow the rate of Wallerian degeneration. We have incubated isolated sciatic nerve segments from wild-type and C57BL/Wld mice (which carry a gene slowing Wallerian degeneration) in… CONTINUE READING
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Temperature modulation shows three stages of Wallerian degeneration

  • JW Tsao, EB George, JW Griffin
  • Soc Neurosci Abstr
  • 1997
1 Excerpt

Axonal degeneration in vitro: effects of temperature and inhibitory chemical compounds

  • JW Tsao, EB George
  • Paper presented at the XVI International Winter…
  • 1996
1 Excerpt

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