Temperature modulation and quadrature detection for selective titration of two-state exchanging reactants.


Biological samples exhibit huge molecular diversity over large concentration ranges. Titrating a given compound in such mixtures is often difficult, and innovative strategies emphasizing selectivity are thus demanded. To overcome limitations inherent to thermodynamics, we here present a generic technique where discrimination relies on the dynamics of… (More)
DOI: 10.1021/ac1026034


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