Temperature-dependent reversible assembly of taxol-treated microtubules

@article{Collins1987TemperaturedependentRA,
  title={Temperature-dependent reversible assembly of taxol-treated microtubules},
  author={Christine A. Collins and Richard B Vallee},
  journal={The Journal of Cell Biology},
  year={1987},
  volume={105},
  pages={2847 - 2854}
}
Taxol is a plant alkaloid that binds to and strongly stabilizes microtubules. Taxol-treated microtubules resist depolymerization under a variety of conditions that readily disassemble untreated microtubules. We report here that taxol-treated microtubules can be induced to disassemble by a combination of depolymerizating conditions. Reversible cycles of disassembly and reassembly were carried out using taxol-containing microtubules from calf brain and sea urchin eggs by shifting temperature in… CONTINUE READING

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References

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Showing 1-10 of 34 references

Identification of a novel force - generating protein , kinesin , involved in microtnhule - based motil

  • R. B. Vallee
  • 1985

Widespread cellular distribution of MAP-IA (microtubule-associated protein IA) in the mitotic spindle and on interphase microtubuies

  • G. S. Bloom, F. C. Luca, R. B. Vallee
  • J. Cell Biol
  • 1984

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