Temperature-dependent higher order structures of the (Pro-Pro-Gly)₁₀-modified dendrimer.

  title={Temperature-dependent higher order structures of the (Pro-Pro-Gly)₁₀-modified dendrimer.},
  author={Tomoyuki Suehiro and Tomoko Tada and Tomonori Waku and Naoki Tanaka and Chizuru Hongo and Shinya Yamamoto and Atsushi Nakahira and Chie Kojima},
  volume={95 4},
Collagen is the most abundant protein in mammals and is widely used as a biomaterial for tissue engineering and drug delivery. We previously reported that dendrimers and linear polymers, modified with collagen model peptides (Pro-Pro-Gly)₅, form a collagen-like triple-helical structure; however, its triple helicity needs improvement. In this study, a collagen-mimic dendrimer modified with the longer collagen model peptides, (Pro-Pro-Gly)₁₀, was synthesized and named PPG10-den. Circular… CONTINUE READING
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