Temperature-dependent chaperone activity and structural properties of human alphaA- and alphaB-crystallins.

@article{Reddy2000TemperaturedependentCA,
  title={Temperature-dependent chaperone activity and structural properties of human alphaA- and alphaB-crystallins.},
  author={G Bhanuprakash Reddy and Kali Pada Das and J. Mark Petrash and Witold K Surewicz},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 7},
  pages={4565-70}
}
The chaperone activity and biophysical properties of recombinant human alphaA- and alphaB-crystallins were studied by light scattering and spectroscopic methods. While the chaperone function of alphaA-crystallin markedly improves with an increase in temperature, the activity of alphaB homopolymer appears to change very little upon heating. Compared with alphaB-crystallin, the alphaA-homopolymer is markedly less active at low temperatures, but becomes a more active species at high temperatures… CONTINUE READING

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