Temperature dependence of poloxamer insertion into and squeeze-out from lipid monolayers.

@article{Frey2007TemperatureDO,
  title={Temperature dependence of poloxamer insertion into and squeeze-out from lipid monolayers.},
  author={Shelli L. Frey and Ka Yee C. Lee},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2007},
  volume={23 5},
  pages={2631-7}
}
F68, a triblock copolymer of the form poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), is found to effectively seal damaged cell membranes. To better understand the molecular interaction between F68 and cells, we have modeled the outer leaflet of a cell membrane with a dipalmitoylphosphatidylcholine (DPPC) monolayer spread at the air-water interface and introduced poloxamer into the subphase. Subsequent interactions of the polymer with the monolayer either upon expansion or… CONTINUE READING

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