Temperature dependence of intracellular pH: Its role in the conservation of pyruvate apparentK m values of vertebrate lactate dehydrogenases

@article{Yancey2004TemperatureDO,
  title={Temperature dependence of intracellular pH: Its role in the conservation of pyruvate apparentK m values of vertebrate lactate dehydrogenases},
  author={Paul H. Yancey and George N Somero},
  journal={Journal of comparative physiology},
  year={2004},
  volume={125},
  pages={129-134}
}
When apparent Michaelis constants (K m's) for pyruvate of M4-lactate dehydrogenases from differently thermally adapted vertebrates are measured at the species' normal cell temperatures, a marked degree of conservation inK m is observed, but only when the pH of the assay medium is varied in the manner in which intracellular pH varies with temperature in most animals (Fig. 2).K m measurements performed at a constant pH do not yield this high degree of interspecific conservation inK m (Figs. 2 and… CONTINUE READING
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