Temperature dependence of ethanol lethality in mice.

  title={Temperature dependence of ethanol lethality in mice.},
  author={R. Malcolm and Ronald L. Alkana},
  journal={The Journal of pharmacy and pharmacology},
  volume={35 5},
The present study provides systematic evidence indicating a direct relationship between environmental temperature, rectal temperature and ethanol lethality. Male, C57 BL/6J mice, previously housed at room temperature (23 +/- 1 degree C), were injected intraperitoneally with 4.8 to 9.2 g kg-1 ethanol and then exposed for 24 h to ambient temperatures that did not appreciably exceed the thermally neutral range for sober mice (20 to 35 degrees C). There was a direct relationship between temperature… CONTINUE READING

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