Temperature dependence of NADPH oxidase in human eosinophils.

  title={Temperature dependence of NADPH oxidase in human eosinophils.},
  author={Deri Morgan and Vladimir Cherny and Ricardo Murphy and Wei Xu and Larry L. Thomas and Thomas E DeCoursey},
  journal={The Journal of physiology},
  volume={550 Pt 2},
The phagocyte NADPH oxidase helps kill pathogens by producing superoxide anion, O2-. This enzyme is electrogenic because it translocates electrons across the membrane, generating an electron current, Ie. Using the permeabilized patch voltage-clamp technique, we studied the temperature dependence of Ie in human eosinophils stimulated by phorbol myristate acetate (PMA) from room temperature to >37 degrees C. For comparison, NADPH oxidase activity was assessed by cytochrome c reduction. The… CONTINUE READING

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