Temperature dependence of IP3-mediated local and global Ca2+ signals.

@article{Dickinson2013TemperatureDO,
  title={Temperature dependence of IP3-mediated local and global Ca2+ signals.},
  author={George D. Dickinson and Ian Parker},
  journal={Biophysical journal},
  year={2013},
  volume={104 2},
  pages={386-95}
}
We examined the effect of temperature (12-40°C) on local and global Ca2+ signals mediated by inositol trisphosphate receptor/channels (IP3R) in human neuroblastoma (SH-SY5Y) cells. The amplitudes and spatial spread of local signals arising from single IP3R (blips) and clusters of IP3R (puffs) showed little temperature dependence, whereas their kinetics (durations and latencies) were markedly accelerated by increasing temperature. In contrast, the amplitude of global Ca2+ waves increased… CONTINUE READING