Temperature dependence of Cav1.4 calcium channel gating.

  title={Temperature dependence of Cav1.4 calcium channel gating.},
  author={Jean B. Peloquin and Clinton J. Doering and Renata Rehak and John E. McRory},
  volume={151 4},
The CACNA1F gene encodes the pore-forming subunit of the L-type Cav1.4 voltage-gated calcium channel (VGCC) and plays a central role in tonic vesicular release at photoreceptor ribbon synapses. The main objective of this study was to examine the effects of temperature on human Cav1.4 cDNA clone VGCCs. With 20 mM Ba2+ as charge carrier, increasing the temperature from 23 degrees C to 37 degrees C increases whole-cell conductance, shifts the voltage-dependence of activation to more hyperpolarized… CONTINUE READING



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