Temperature and enantioseparation by macrocyclic glycopeptide chiral stationary phases.

@article{Berthod2004TemperatureAE,
  title={Temperature and enantioseparation by macrocyclic glycopeptide chiral stationary phases.},
  author={Alain Berthod and Brian Lingfeng He and Thomas E. Beesley},
  journal={Journal of chromatography. A},
  year={2004},
  volume={1060 1-2},
  pages={
          205-14
        }
}
Seventy-one chiral compounds were separated on four macrocyclic glycopeptide chiral selectors: teicoplanin, its aglycone, ristocetin A and vancomycin, using three possible separation modes: reversed phase with methanol/buffer mobile phases, normal phase with hexane/ethanol mobile phases and polar ionic mode (PIM) with 100% methanol mobile phase with trace amounts of acid and/or base. These 148 separations were studied in a 5-45 degrees C temperature range. Peak efficiencies always increased… CONTINUE READING
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