Temperature and acid-base balance in ectothermic vertebrates: the imidazole alphastat hypotheses and beyond.

@article{Burton2002TemperatureAA,
  title={Temperature and acid-base balance in ectothermic vertebrates: the imidazole alphastat hypotheses and beyond.},
  author={Richard F. Burton},
  journal={The Journal of experimental biology},
  year={2002},
  volume={205 Pt 23},
  pages={3587-600}
}
The 'imidazole alphastat hypothesis' states that intracellular and extracellular pH, partly via buffering by imidazole groups, change with temperature in a way that keeps imidazole and protein ionization constant, thus maintaining cell function and minimizing shifts of base equivalents and total CO(2), while adjustment of P(CO(2)) involves imidazole-based receptors. 'The hypothesis', which is actually several hypotheses, has been variously perceived and judged, but its underlying conceptual… CONTINUE READING

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The equations utilize a single , notional , temperature - dependent pK value for all non - bicarbonate buffers in a given body compartment .
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