Temperature-Dependent Structural Variability of RNAs: spliced Leader RNAs and their Evolutionary History

@article{Marz2010TemperatureDependentSV,
  title={Temperature-Dependent Structural Variability of RNAs: spliced Leader RNAs and their Evolutionary History},
  author={Manja Marz and Nathalie Vanzo and Peter F. Stadler},
  journal={Journal of bioinformatics and computational biology},
  year={2010},
  volume={8 1},
  pages={
          1-17
        }
}
The structures attained by RNA molecules depend not only on their sequence but also on environmental parameters such as their temperature. So far, this effect has been largely neglected in bioinformatics studies. Here, we show that structural comparisons can be facilitated and more coherent structural models can be obtained when differences in environmental parameters are taken into account. We re-evaluate the secondary structures of the spliced leader (SL) RNAs from the seven eukaryotic phyla… CONTINUE READING