Temperament trait Harm Avoidance associates with μ-opioid receptor availability in frontal cortex: A PET study using [11C]carfentanil

@article{Tuominen2012TemperamentTH,
  title={Temperament trait Harm Avoidance associates with $\mu$-opioid receptor availability in frontal cortex: A PET study using [11C]carfentanil},
  author={Lauri Tuominen and Johanna Salo and Jussi Hirvonen and Kjell N{\aa}gren and P Laine and Tarja Melartin and Erkki Tapio Isomets{\"a} and Jorma S. Viikari and Olli T. Raitakari and Liisa Keltikangas-J{\"a}rvinen and Jarmo Hietala},
  journal={NeuroImage},
  year={2012},
  volume={61},
  pages={670-676}
}
Harm Avoidance is a temperament trait that associates with sensitivity to aversive and non-rewarding stimuli, higher anticipated threat and negative emotions during stress as well as a higher risk for affective disorders. The neurobiological correlates of interindividual differences in Harm Avoidance are largely unknown. We hypothesized that variability in Harm Avoidance trait would be explained by differences in the activity of μ-opioid system as the opioid system is known to regulate… 
A positive relationship between harm avoidance and brain nicotinic acetylcholine receptor availability
TLDR
Findings may indicate that heightened cholinergic neurotransmission is associated with increased anxiety-like traits, and may prove useful in understanding the pathophysiology of psychiatric disorders that have similar characteristics to HA.
Behavioural activation system sensitivity is associated with cerebral μ-opioid receptor availability.
TLDR
The results suggest that endogenous opioid system underlies BAS, and that differences in MOR availability could explain inter-individual differences in reward seeking behaviour.
Dorsal raphe nucleus and harm avoidance: A resting-state investigation
TLDR
Evidence is provided that at rest, signal intensity fluctuations within the dorsal raphe networks are related to harm avoidance, given the strong relationship between harm avoidance and anxiety-like behaviors.
Lowered endogenous mu-opioid receptor availability in subclinical depression and anxiety
TLDR
It is concluded that dysregulated MOR availability is involved in altered mood and pathophysiology of depression and anxiety disorders.
μ-opioid receptor availability is associated with sex drive in human males.
TLDR
It is concluded that endogenous MOR tone is associated with individual differences in sex drive in human males, in line with high spatial autocorrelation in MOR expression in human brain.
μ-opioid receptor availability is associated with sex drive in human males
TLDR
It is concluded that endogenous MOR tone is associated with individual differences in sex drive in human males, in line with high spatial autocorrelation in MOR expression in human brain.
Adult Attachment System Links With Brain Mu Opioid Receptor Availability In Vivo.
TLDR
Preliminary in vivo evidence is provided that the opioid system may be involved in the neurocircuits associated with individual differences in adult attachment behavior and suggests variation in mu opioid receptor availability may be linked with the individuals' social relationships and psychosocial well-being and thus contributes to risk for psychiatric morbidity.
Anxiety and Harm Avoidance
Abstract Harm avoidance is a biologically informed conceptualization of trait anxiety. It reflects the heritable tendency to react strongly to punishment or frustration by inhibiting ongoing
Harm avoidance is associated with progression of parkinsonism in community-dwelling older adults: a prospective cohort study
TLDR
The association between harm avoidance and progression of parkinsonism persisted when controlling for cognitive function, depressive symptoms, loneliness, neuroticism, late-life cognitive, social and physical activities and chronic health conditions.
Opioid system and human emotions
TLDR
Taken together, the opioid systems contribute to a wide array of positive and negative emotions through their general ability to modulate the approach versus avoidance motivation associated with specific emotions.
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