Temozolomide responsiveness in aggressive corticotroph tumours: a case report and review of the literature

@article{Annamalai2011TemozolomideRI,
  title={Temozolomide responsiveness in aggressive corticotroph tumours: a case report and review of the literature},
  author={Anand Kumar Annamalai and Andrew F Dean and Narayanan Kandasamy and K{\'a}lm{\'a}n Kov{\'a}cs and Hannah M.M. Burton and David John Halsall and Andrey S Shaw and Nagui M. Antoun and Heok Keong Cheow and Ramez Wadie Kirollos and John D. Pickard and Helen L. Simpson and Sarah J. Jefferies and Neil G. Burnet and Mark Gurnell},
  journal={Pituitary},
  year={2011},
  volume={15},
  pages={276-287}
}
Pituitary carcinoma occurs in ~0.2% of resected pituitary tumours and carries a poor prognosis (mean survival <4 years), with standard chemotherapy regimens showing limited efficacy. Recent evidence suggests that temozolomide (TMZ), an orally-active alkylating agent used principally in the management of glioblastoma, may also be effective in controlling aggressive/invasive pituitary adenomas/carcinomas. A low level of expression of the DNA-repair enzyme O6-methylguanine-DNA methyltransferase… CONTINUE READING

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The role of temozolomide in the treatment of aggressive pituitary tumors.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia • 2015
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