Temozolomide-mediated radiosensitization of human glioma cells in a zebrafish embryonic system.

@article{Geiger2008TemozolomidemediatedRO,
  title={Temozolomide-mediated radiosensitization of human glioma cells in a zebrafish embryonic system.},
  author={Geoffrey A. Geiger and Weili Fu and Gary D. Kao},
  journal={Cancer research},
  year={2008},
  volume={68 9},
  pages={3396-404}
}
The zebrafish (Danio rerio) is a popular vertebrate model for biomedical research. The rapid development, transparency, and experimental accessibility of the embryo offer opportunities for assessing the developmental effects of anticancer treatment strategies. We therefore systematically investigated parameters for growing U251 human glioma cells expressing red fluorescent protein (U251-RFP) in zebrafish embryos. Factors optimized include injection volume, number of cells injected, anatomic… CONTINUE READING