Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.

@article{Wick2012TemozolomideCA,
  title={Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.},
  author={W Wick and Michael Platten and C. Meisner and Joerg Felsberg and Ghazaleh Tabatabai and Miranda Simon and Guido Nikkhah and Kirsten Papsdorf and Joachim Peter Steinbach and Michael Christoph Sabel and Stephanie E Combs and Jan Vesper and Christian Braun and J{\"u}rgen Meixensberger and Ralf Ketter and Regine Mayer-Steinacker and Guido Reifenberger and Michael Weller},
  journal={The Lancet. Oncology},
  year={2012},
  volume={13 7},
  pages={707-15}
}
BACKGROUND Radiotherapy is the standard care in elderly patients with malignant astrocytoma and the role of primary chemotherapy is poorly defined. We did a randomised trial to compare the efficacy and safety of dose-dense temozolomide alone versus radiotherapy alone in elderly patients with anaplastic astrocytoma or glioblastoma. METHODS Between May 15, 2005, and Nov 2, 2009, we enrolled patients with confirmed anaplastic astrocytoma or glioblastoma, age older than 65 years, and a Karnofsky… CONTINUE READING
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