Temozolomide and methotrexate for primary central nervous system lymphoma in the elderly

@article{Omuro2007TemozolomideAM,
  title={Temozolomide and methotrexate for primary central nervous system lymphoma in the elderly},
  author={A Omuro and Luc Taillandier and Olivier L. Chinot and Charlotte Carnin and Maryline Barri{\'e} and Kh{\^e} Hoang-Xuan},
  journal={Journal of Neuro-Oncology},
  year={2007},
  volume={85},
  pages={207-211}
}
Treatment for primary CNS lymphoma (PCNSL) in the elderly is associated with lower response rates and higher risks of acute and late delayed toxicity as compared to younger patients. Temozolomide has emerged as a new alternative treatment for PCNSL and constitutes an attractive option for the elderly because of its favorable toxicity profile. In this study we report outcomes of a consecutive series of PCNSL elderly patients initially treated with an innovative regimen combining methotrexate and… CONTINUE READING
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