Temozolomide Delivery to Tumor Cells by a Multifunctional Nano Vehicle Based on Poly(β-L-malic acid)

@article{Patil2010TemozolomideDT,
  title={Temozolomide Delivery to Tumor Cells by a Multifunctional Nano Vehicle Based on Poly(β-L-malic acid)},
  author={Rameshwar Patil and Jos{\'e} Portilla-Arias and Hui Ding and Satoshi Inoue and Bindu Konda and Jinwei Hu and Kolja A. Wawrowsky and Paul K. S. Shin and Keith L. Black and Eggehard Holler and Julia Y. Ljubimova},
  journal={Pharmaceutical Research},
  year={2010},
  volume={27},
  pages={2317-2329}
}
Temozolomide (TMZ) is a pro-drug releasing a DNA alkylating agent that is the most effective drug to treat glial tumors when combined with radiation. TMZ is toxic, and therapeutic dosages are limited by severe side effects. Targeted delivery is thus needed to improve efficiency and reduce non-tumor tissue toxicity. Multifunctional targetable nanoconjugates of TMZ hydrazide were synthesized using poly(β-L-malic acid) platform, which contained a targeting monoclonal antibody to transferrin… CONTINUE READING

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