Temozolomide Delivered by Intracerebral Microinfusion is Safe and Efficacious Against Malignant Gliomas in Rats 1

@inproceedings{Heimberger2000TemozolomideDB,
  title={Temozolomide Delivered by Intracerebral Microinfusion is Safe and Efficacious Against Malignant Gliomas in Rats 1},
  author={Amy Heimberger and Gary E. Archer and Roger E McLendon and Christine Hulette and Allan H. Friedman and Henry S. Friedman and Darell D Bigner and John H. Sampson},
  year={2000}
}
Intracerebral microinfusion (ICM) is an innovative technique of delivering therapeutic agents throughout large portions of the brain that circumvents the blood-brain barrier, minimizes systemic toxicity, and provides a homogeneous distribution of the infused agent. Temozolomide is a novel methylating agent with proven efficacy against malignant gliomas (MGs… CONTINUE READING