Temazepam Triggers the Release of Vasopressin into the Rat Hypothalamic Paraventricular Nucleus: Novel Insight into Benzodiazepine Action on Hypothalamic–Pituitary–Adrenocortical System Activity During Stress

@article{Welt2006TemazepamTT,
  title={Temazepam Triggers the Release of Vasopressin into the Rat Hypothalamic Paraventricular Nucleus: Novel Insight into Benzodiazepine Action on Hypothalamic–Pituitary–Adrenocortical System Activity During Stress},
  author={T. Welt and M. Engelmann and U. Renner and A. Erhardt and Marianne B. M{\"u}ller and R. Landgraf and F. Holsboer and M. Keck},
  journal={Neuropsychopharmacology},
  year={2006},
  volume={31},
  pages={2573-2579}
}
We investigated the influence of a representative classical benzodiazepine on the regulation of the hypothalamic–pituitary–adrenocortical (HPA) axis activity both under basal conditions and stress. Adult male Wistar rats were intravenously administered with temazepam (0.5, 1, and 3 mg/kg body weight) and plasma concentrations of corticotropin (ACTH) and vasopressin (AVP) were measured in blood samples collected via chronically implanted jugular venous catheters. Simultaneously, the release of… Expand
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