Telomerization as a Method of Obtaining Immortal Human Cells Preserving Normal Properties

@article{Yegorov2003TelomerizationAA,
  title={Telomerization as a Method of Obtaining Immortal Human Cells Preserving Normal Properties},
  author={Ye. E. Yegorov and Sergey M Terekhov and Kh. S. Vishnyakova and Dmitry Karachentsev and E. V. Kazimirchuk and Tetiana Tsvetkova and Nataliya N Veiko and Tatiana D. Smirnova and A. S. Makarenkov and M. A. El'darov and Yu. A. Meshcheryakova and Nataliya A. Lyapunova and Alexandr V. Zelenin},
  journal={Russian Journal of Developmental Biology},
  year={2003},
  volume={34},
  pages={145-153}
}
Most human somatic cells have no telomerase activity. This leads to terminal underreplication of chromosomes and, hence, proliferative ageing of cells. We studied the consequences of introduction of the gene of the catalytic component of human telomerase hTERT in the normal fibroblasts of adult human skin. The expression of this gene led to the appearance of telomerase activity in the fibroblasts, elongation of telomeres (to the size characteristic of the embryonic cells), and immortalization… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 42 references

Struktural-Funktional Organization of Ribosomal Human Repeats

  • N. N. Veiko
  • Doctoral (Biol.) Dissertation,
  • 2001
Highly Influential
3 Excerpts

Immortalization of Normal Fibroblasts of Adult Human Skin by Introduction of the Gene of Catalytic Component of Telomerase

  • E. E. Yegorov, S. M. Terekhov, Vishnyakova, Kh.S
  • Biol. Membr., 2002c,
  • 2002
1 Excerpt

Methyla - tion , Abundance , and Activity of Ribosomal Genes Remain Unchanged after “ Telomerization ” of Human Fibroblasts , Dokl

  • E. E. Yegorov, N. N. Veiko, T. G. Tsvetkova
  • 2002
1 Excerpt

Methylation, Abundance, and Activity of Ribosomal Genes Remain Unchanged after “Telomerization

  • E. E. Yegorov, N. N. Veiko, Tsvetkova, T.G
  • Human Fibroblasts, Dokl. Ross. Akad. Nauk, 2002b,
  • 2002
1 Excerpt

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