Telomeric chromatin: replicating and wrapping up chromosome ends.

  title={Telomeric chromatin: replicating and wrapping up chromosome ends.},
  author={David Shore},
  journal={Current opinion in genetics & development},
  volume={11 2},
  • David Shore
  • Published 2001 in Current opinion in genetics & development
Recent advances in our understanding of the specialized chromatin structure at telomeres, the ends of eukaryotic chromosomes, have focused on three separate areas: replication of telomeres through the coordinated action of conventional DNA polymerases and the telomerase enzyme, protection of the chromosome end from DNA damage checkpoint sensors and DNA-repair processes, and the discovery of a novel deacetylase enzyme (Sir2p) required for the establishment and maintenance of telomeric… CONTINUE READING