Telomeric Repeat–Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends

@article{Azzalin2007TelomericRR,
  title={Telomeric Repeat–Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends},
  author={Claus M. Azzalin and Patrick Reichenbach and Lela Khoriauli and Elena Giulotto and Joachim Lingner},
  journal={Science},
  year={2007},
  volume={318},
  pages={798 - 801}
}
Telomeres, the DNA-protein complexes located at the end of linear eukaryotic chromosomes, are essential for chromosome stability. Until now, telomeres have been considered to be transcriptionally silent. We demonstrate that mammalian telomeres are transcribed into telomeric repeat–containing RNA (TERRA). TERRA molecules are heterogeneous in length, are transcribed from several subtelomeric loci toward chromosome ends, and localize to telomeres. We also show that suppressors with morphogenetic… 
TERRA: telomeric repeat-containing RNA
TLDR
TERRA functions that are emerging suggest important roles in the regulation of telomerase and in orchestrating chromatin remodelling throughout development and cellular differentiation.
Telomeric noncoding RNA: telomeric repeat‐containing RNA in telomere biology
TLDR
The study of the molecular mechanisms of TERRA biogenesis and function may advance the understanding of telomere‐related diseases, including cancer and aging.
Characterization of human telomeric repeat-containing RNA biogenesis and function
TLDR
It is found that at least 20 human subtelomeres contain a CpG-island and that these CpGs are bound by active RNAPII in vivo and found that TERRA transcription is negatively regulated through cytosine methylation at the Cpg-islands.
Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity
TLDR
Recent developments on TERRA's role in telomere biology and genome integrity, and its implication in cancer are discussed.
TERRA: Long Noncoding RNA at Eukaryotic Telomeres.
TLDR
This chapter summarizes the current knowledge of telomere structure and function and extensively review data accumulated on TERRA biogenesis and regulation and discusses putative functions of TERRA in preserving telomeres stability.
The differential processing of telomeres in response to increased telomeric transcription and RNA–DNA hybrid accumulation
TLDR
It is demonstrated that despite these similar phenotypic outcomes, telomeres that are highly transcribed are not processed in the same manner as those that accumulate RNA–DNA hybrids.
RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops
TLDR
A reporter system is developed and a RAD51-dependent pathway that governs TERRA-mediated R-loop formation after transcription is revealed, providing a mechanism for the recruitment of lncRNAs to new loci in trans.
Chromatin regulation and non-coding RNAs at mammalian telomeres.
TLDR
Understanding the links between the epigenetic status of telomeres, TERRA/TelRNA and telomere homeostasis will open new avenues for the understanding of organismal development, cancer and ageing.
Transcription regulates telomere dynamics in human cancer cells.
TLDR
It is shown that the transcriptional activity of human telomeres directly regulates their movement during interphase, and it is found that chemical inhibition of global transcription dampens telomere motion, while global stimulation promotes it.
Telomeric Repeat-Containing RNA (TERRA) and Telomerase Are Components of Telomeres During Mammalian Gametogenesis1
TLDR
It is found that TERRA colocalizes with telomeres during mammalian meiosis and that its expression progressively increases during spermatogenesis until the beginning of spermiogenesis, the first evidence of colocalization between telomerase and telomere-TERT during mammalian gametogenesis.
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