Telomeres shorten while Tert expression increases during ageing of the short-lived fish Nothobranchius furzeri

  title={Telomeres shorten while Tert expression increases during ageing of the short-lived fish Nothobranchius furzeri},
  author={N. Hartmann and K. Reichwald and A. Lechel and M. Graf and C. Englert},
  journal={Mechanisms of Ageing and Development},
  • N. Hartmann, K. Reichwald, +2 authors C. Englert
  • Published 2009
  • Biology, Medicine
  • Mechanisms of Ageing and Development
  • Age research in vertebrates is often limited by the longevity of available models. The teleost fish Nothobranchius furzeri has an exceptionally short lifespan with 3.5 months for the laboratory strain GRZ and about 6 months for the wild-derived strain MZM-0403. Here we have investigated telomere length in muscle and skin tissue of young and old fish of both strains using different methods. We found age-dependent telomere shortening in the MZM-0403 strain with the longer lifespan, whereas the… CONTINUE READING
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