Telomeres shorten while Tert expression increases during ageing of the short-lived fish Nothobranchius furzeri
@article{Hartmann2009TelomeresSW,
title={Telomeres shorten while Tert expression increases during ageing of the short-lived fish Nothobranchius furzeri
},
author={Nils Hartmann and Kathrin Reichwald and Andr{\'e} Lechel and Michael Graf and Jeanette Kirschner and Alexander Dorn and Eva Tozzini Terzibasi and Julia S. Wellner and Matthias Platzer and Karl Lenhard Rudolph and Alessandro Cellerino and Christoph Englert},
journal={Mechanisms of Ageing and Development},
year={2009},
volume={130},
pages={290-296}
}
106 Citations
Mitochondrial DNA copy number and function decrease with age in the short‐lived fish Nothobranchius furzeri
- BiologyAging cell
- 2011
Investigation of possible changes in mitochondrial function revealed that the content of respiratory chain complexes III and IV was reduced in skeletal muscle with age and ADP‐stimulated and succinate‐dependent respiration was decreased in mitochondria of old fish.
Absence of replicative senescence in cultured cells from the short-lived killifish Nothobranchius furzeri
- BiologyExperimental Gerontology
- 2013
Expression of Telomerase and Telomere Length Are Unaffected by either Age or Limb Regeneration in Danio rerio
- Biology, MedicinePloS one
- 2009
The ongoing study of the zebrafish's ability to maintain telomerase activity may be helpful in unraveling the complexity involved in the maintenance of telomeres in other species such the mouse or human.
High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research
- BiologyGenome Biology
- 2008
This work presents a first basis for systematic genomic and genetic analyses aimed at understanding the mechanisms of life span determination in N. furzeri and provides a first insight into its genome and a comparison to medaka, stickleback, tetraodon and zebrafish.
Age and Heat Stress as Determinants of Telomere Length in a Long-Lived Fish, the Siberian Sturgeon
- BiologyPhysiological and Biochemical Zoology
- 2016
In the Siberian sturgeon, a significant telomere shortening with age is found, both at the intraindividual level using red blood cells (−12.5% in 16 mo) and at the interindividual level using cross-sectional samples of fin over an age range of 8 yr.
The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into age-dependent changes of mRNA levels
- BiologyBMC Genomics
- 2012
A comprehensive, annotated N. furzeri transcript catalogue is provided and a first transcriptome-wide insight into N. Furzeri ageing is provided, suggesting that ageing is accelerated in the short-lived N.furzeri strain GRZ compared to the longer-lived strain MZM-0403.
Characterization of telomeres and telomerase expression in Xiphophorus.
- BiologyComparative biochemistry and physiology. Toxicology & pharmacology : CBP
- 2012
Comparison of captive lifespan, age-associated liver neoplasias and age-dependent gene expression between two annual fish species: Nothobranchius furzeri and Nothobranchius korthause
- BiologyBiogerontology
- 2014
The different ageing rate of two species of the same genus could be used as novel tool to investigate and better understand the genetic bases of some general mechanism leading to the complex ageing process, providing a strategy to unravel some of the genetic mechanisms regulating longevity and age-associate pathologies including neoplasias.
Environment and sex control lifespan and telomere length in wild-derived African killifish
- BiologybioRxiv
- 2020
It is found that males had shorter telomeres than females and substantial variation in telomere length between strains from different environments provides killifish as powerful tool to understand the evolutionarily adaptive value of telomer length.
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