Telomeres shorten during ageing of human fibroblasts

@article{Harley1990TelomeresSD,
  title={Telomeres shorten during ageing of human fibroblasts},
  author={Calvin B. Harley and A. Bruce Futcher and Carol W Greider},
  journal={Nature},
  year={1990},
  volume={345},
  pages={458-460}
}
THE terminus of a DNA helix has been called its Achilles' heel1. Thus to prevent possible incomplete replication2 and instability3,4 of the termini of linear DNA, eukaryotic chromosomes end in characteristic repetitive DNA sequences within specialized structures called telomeres5. In immortal cells, loss of telomeric DNA due to degradation or incomplete replication is apparently balanced by telomere elongation6–10, which may involve de novo synthesis of additional repeats by a novel DNA… CONTINUE READING
Highly Influential
This paper has highly influenced 68 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS