Telomeres shorten at equivalent rates in somatic tissues of adults

@inproceedings{Daniali2013TelomeresSA,
  title={Telomeres shorten at equivalent rates in somatic tissues of adults},
  author={Lily N. Daniali and Athanase B{\'e}n{\'e}tos and Ezra Saul Susser and Jeremy David Kark and Carlos Labat and Masayuki Kimura and Kunji Desai and Mark S. Granick and Abraham Aviv},
  booktitle={Nature communications},
  year={2013}
}
Telomere shortening in somatic tissues largely reflects stem cell replication. Previous human studies of telomere attrition were predominantly conducted on leukocytes. However, findings in leukocytes cannot be generalized to other tissues. Here we measure telomere length in leukocytes, skeletal muscle, skin and subcutaneous fat of 87 adults (aged 19-77 years). Telomeres are longest in muscle and shortest in leukocytes, yet are strongly correlated between tissues. Notably, the rates of telomere… CONTINUE READING
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