Telomeres in T and B cells

  title={Telomeres in T and B cells},
  author={Richard J Hodes and Karen S. Hathcock and Nan-ping Weng},
  journal={Nature Reviews Immunology},
Telomeres are the structures at the ends of linear chromosomes. In mammalian cells, they consist of hexanucleotide (TTAGGG) repeats, together with many associated proteins. In the absence of a compensatory mechanism, dividing cells undergo gradual telomere erosion until a critical degree of shortening results in chromosomal abnormalities and cell death or senescence. For T and B cells, the ability to undergo extensive cell division and clonal expansion is crucial for effective immune function… CONTINUE READING