Telomeres and telomerase in lung cancer.

@article{FernandezGarcia2008TelomeresAT,
  title={Telomeres and telomerase in lung cancer.},
  author={Ignacio Fernandez-Garcia and Carlos Ortiz-de-Solorzano and Luis M. Montuenga},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2008},
  volume={3 10},
  pages={1085-8}
}
Protected telomeres ensure normal chromosomal segregation during mitosis but at the same time can endow genetically abnormal cancer cells with immortality. Telomerase has a pivotal role in telomere protection, both in normal and cancer cells. Understanding the functional interplay between telomere shortening and telomerase expression in cancer cells is of critical importance to elucidating the precise mechanisms by which these cells are able to bypass telomere crisis and become immortal. 

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Clinical and immunologic response of patients with advanced solid tumors vaccinated with an optimized cryptic hTERT peptide ( Vx001 ) . ( 2008 ASCO Annual Meeting )

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Clinical and immunologic response of patients with advanced solid tumors vaccinated with an optimized cryptic hTERT peptide (Vx-001)

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