Telomeres and human disease: ageing, cancer and beyond

@article{Blasco2005TelomeresAH,
  title={Telomeres and human disease: ageing, cancer and beyond},
  author={M. Blasco},
  journal={Nature Reviews Genetics},
  year={2005},
  volume={6},
  pages={611-622}
}
  • M. Blasco
  • Published 2005
  • Medicine, Biology
  • Nature Reviews Genetics
  • Telomere length and telomerase activity are important factors in the pathobiology of human disease. Age-related diseases and premature ageing syndromes are characterized by short telomeres, which can compromise cell viability, whereas tumour cells can prevent telomere loss by aberrantly upregulating telomerase. Altered functioning of both telomerase and telomere-interacting proteins is present in some human premature ageing syndromes and in cancer, and recent findings indicate that alterations… CONTINUE READING

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