Telomeres, telomerase and cancer: an up-date

@article{Dhaene2000TelomeresTA,
  title={Telomeres, telomerase and cancer: an up-date},
  author={Karl Dhaene and E. Van Marck and Reza Parwaresch},
  journal={Virchows Archiv},
  year={2000},
  volume={437},
  pages={1-16}
}
Abstract In the mid 1990s, the hypothesis emerged that the upregulation or re-expression of a telomere- synthesising ribonucleoprotein, called telomerase, is a critical event responsible for continuous tumour cell growth. In contrast to normal cells, in which gradual mitosis-related erosion of telomeres eventually limits replicative life span, tumour cells have telomerase and show no loss of these chromosomal ends. These data suggest that telomere stabilisation may be required for cells to… CONTINUE READING

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