Telomeres, telomerase, and aging: Origin of the theory

@article{Olovnikov1996TelomeresTA,
  title={Telomeres, telomerase, and aging: Origin of the theory},
  author={Alexey M. Olovnikov},
  journal={Experimental Gerontology},
  year={1996},
  volume={31},
  pages={443-448}
}
  • A. Olovnikov
  • Published 1 July 1996
  • Biology
  • Experimental Gerontology
View on Elsevier
doi.org
362 Citations
Highly Influential Citations
12
Background Citations
140
Methods Citations
3
Results Citations
1

362 Citations

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Citation Type

Telomere recombination in normal mammalian cells
TLDR
The present review describes the morphological and functional reorganizations of mammalian telomeres observed with ALT activation, as well as recently observed and well-documented cases of combinations between ALT-like and telomerase-dependent mechanisms in mammalian cells.
Mechanisms of Telomere Protection and Deprotection in Human Cells
Telomeres, the nucleo-protein complexes at the ends of linear chromosomes, have critical roles in genome stability, cancer, and aging. Early work by B. McClintock and H.J. Muller demonstrated that…
Defining the steps that lead to cancer: replicative telomere erosion, aneuploidy and an epigenetic maturation arrest of tissue stem cells.
18 Cellular Senescence and Its Relation with Telomere
TLDR
It is shown that senescence possesses a beneficial effect for the organism because it would avoid the development of cancer; otherwise, the second hypothesis would exert a harmful effect on organisms in that it would favor aging.
Functional human telomeres are recognized as DNA damage in G2 of the cell cycle.
Cellular Senescence and Its Relation with Telomere
TLDR
It is shown that senescence possesses a beneficial effect for the organism because it would avoid the development of cancer; otherwise, the second hypothesis would exert a harmful effect on organisms in that it would favor aging.
Telomeres and Telomerase in Human Health and Disease
TLDR
Unraveling the detailed mechanisms involved in the regulation of telomere length and telomerase activity will have important and far-reaching implications in understanding many aspects of human health and disease, ranging from accelerated aging syndromes to cancer pathogenesis, among others.
The root of ageing lies in telomere: A review article
Telomeres play a vital position in cellular destiny and developing antique with the resource of adjusting the cellular reaction to stress and increase stimulation on the idea of previous cell…
Telomeric aging: mitotic clock or stress indicator?
Telomeres are regions of tandem arrays of TTAGGG repeats and associated proteins located at chromosomal ends that allow cells to distinguish chromosome ends from double-strand breaks and protect…
Inter-telomeric recombination is present in telomerase-positive human cells
TLDR
It is shown that homologous recombination between telomeres is detectable in ALT cells with the same frequency as in cells that utilize the telomerase pathway, and inter-telomeric recombination is present in both pathways of telomere length control.
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References

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Telomeres shorten during ageing of human fibroblasts
TLDR
The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.
Telomere loss: mitotic clock or genetic time bomb?
Telomerase and telomere-length regulation: lessons from small eukaryotes to mammals.
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  • Biology
    Cold Spring Harbor symposia on quantitative biology
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TLDR
The pioneering work of Muller and McClintock defined the telomere as the functional end of the chromosome, which is distinct from a random broken end.
Telomere end-replication problem and cell aging.
Telomeres: No end in sight
Growth and death of diploid and transformed human fibroblasts.
TLDR
It can be shown that speeding up the rate at which the error catastrophe develops, as may occur in transformed cells, can convert a population of finite life-span to one with infinite growth.
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
Chromosome ends in Drosophila without telomeric DNA sequences.
TLDR
Molecular cloning and sequencing of the terminal DNA fragments revealed that the broken ends of the deleted chromosomes do not carry any telomeric DNA sequences, yet the broken chromatids do not fuse to one another.
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.
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