Telomeres, p53 and cellular senescence.

Abstract

The ability of mammalian cells to respond to extrinsic mitogens is downregulated in response to proliferative aging (senescence), and it is now likely that at least a subset of such lifespan checkpoints is triggered by a biological "clock" based on erosion of chromosome telomeres. This review outlines the intrinsic inhibitory signal pathways that link this… (More)

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