Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region

@inproceedings{Therizols2006TelomereTA,
  title={Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region},
  author={Pierre Therizols and C. Fairhead and Ghislain G. Cabal and Auguste Genovesio and Jean-Christophe Olivo-Marin and Bernard Dujon and Emmanuelle Fabre},
  booktitle={The Journal of cell biology},
  year={2006}
}
In the yeast Saccharomyces cerevisiae that lacks lamins, the nuclear pore complex (NPC) has been proposed to serve a role in chromatin organization. Here, using fluorescence microscopy in living cells, we show that nuclear pore proteins of the Nup84 core complex, Nup84p, Nup145Cp, Nup120p, and Nup133p, serve to anchor telomere XI-L at the nuclear periphery. The integrity of this complex is shown to be required for repression of a URA3 gene inserted in the subtelomeric region of this chromosome… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 92 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Limitations of silencing at native yeast telomeres.

The EMBO journal • 1999
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…