Telomere shortening in liver transplant recipients is not influenced by underlying disease or metabolic derangements.

@article{Uziel2013TelomereSI,
  title={Telomere shortening in liver transplant recipients is not influenced by underlying disease or metabolic derangements.},
  author={Orit Uziel and Ido Laish and Marina Bulcheniko and Yael Harif and Naama Kochavi-Shalem and Maya Aharoni and Rony Braunstein and Meir Lahav and Ziv Z Ben-Ari},
  journal={Annals of transplantation},
  year={2013},
  volume={18},
  pages={567-75}
}
BACKGROUND Telomeres are non-coding regions of DNA that cap the ends of chromosomes. Their length is considered a marker of human replicative senescence and premature aging. Given the high association of liver transplantation with the metabolic syndrome, we hypothesized that liver transplant recipients may exhibit premature and accelerated aging. MATERIAL AND METHODS Telomere length in peripheral blood lymphocytes was measured by polymerase chain reaction in 62 consecutive liver-transplant… CONTINUE READING
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